Reaktion #157309

Reaktionsgleichung

3-Hydroxy-2-aminopyridine

potassium hydroxide

carbon disulfide

→

title compound

Ausbeute 91.0%

Oxazolo[4,5-b]pyridine-2(3H)-thione

Ausbeute 91.0%

Lösungsmittel

EtOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto reflux overnight
2. 2
   Einengenthe reaction mixture was concentrated under reduced pressure
3. 3
   Filtrationcollected by filtration
4. 4
   Waschenwashed with water (2×)
5. 5
   Sonstigeair-dried
6. 6
   SonstigeFurther drying in a 35° C. vacuum oven

Vorschrift

3-Hydroxy-2-aminopyridine (2.00 g, 18.2 mmol) and potassium hydroxide (1.22 g, 21.8 mmol) were dissolved in carbon disulfide (15 mL) and EtOH (25 mL), and the reaction mixture was heated to reflux overnight. Upon cooling to rt, the reaction mixture was concentrated under reduced pressure. The resulting solid was suspended in 1 M aqueous HCl, collected by filtration, washed with water (2×) and air-dried. Further drying in a 35° C. vacuum oven gave 2.52 g (91%) of the title compound as a tan solid. LC-MS: RT=4.82 min., [M+H]+=153.1

Quelle