Reaktion #157228

ord-50325b94a4464531a196d523fc35d85c

Reaktionsgleichung

COc1cc(C(=O)c2csc(-c3ccccc3)n2)cc(OC)c1OC
compound 1h
COc1cc(C(=O)c2csc(-c3ccccc3)n2)cc(OC)c1OC
(2-Phenyl-thiazol-4-yl)-(3,4,5-trimethoxy-phenyl)-methanone
CN(C)c1ccc(C#N)cc1
4-(dimethylamino)benzonitrile
N[C@@H](CS)C(=O)O
cysteine
→
COc1cc(C(=O)c2csc(-c3ccc(N(C)C)cc3)n2)cc(OC)c1OC
(2-(4-(Dimethylamino)phenyl)thiazol-4-yl)(3,4,5-trimethoxyphenyl)methanone

Edukte

COc1cc(C(=O)c2csc(-c3ccccc3)n2)cc(OC)c1OC
compound 1h
COc1cc(C(=O)c2csc(-c3ccccc3)n2)cc(OC)c1OC
(2-Phenyl-thiazol-4-yl)-(3,4,5-trimethoxy-phenyl)-methanone
CN(C)c1ccc(C#N)cc1
4-(dimethylamino)benzonitrile
N[C@@H](CS)C(=O)O
cysteine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

(2-(4-(Dimethylamino)phenyl)thiazol-4-yl)(3,4,5-trimethoxyphenyl)methanone (2o) was prepared using the same method as used of compound 1h from 4-(dimethylamino)benzonitrile and cysteine. NMR (300 MHz, CDCl3) δ 8.12 (s, 1H), 7.88 (d, 2H), 7.80 (s, 2H), 6.73 (d, 2H), 3.96 (s, 3H), 3.95 (s, 6H), 3.05 (s, 6H); MS (ESI) m/z 421.1 (M+Na)+.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08822513B2uspto-grants-2014_09