Reaktion #1571585

ord-283924a3de194058becdb131d92edc24

Reaktionsgleichung

CCCCC[C@H](O)CC[C@@H]1[C@H]2Cc3cccc(OCC(=O)O)c3C[C@H]2C[C@H]1O
Treprostinil
CCO
ethanol
O
water
OCCNCCO
diethanolamine
→
CCCCC[C@H](O)CC[C@@H]1[C@H]2Cc3cccc(OCC(=O)O)c3C[C@H]2C[C@H]1O.OCCNCCO
Treprostinil Diethanolamine

Edukte

CCCCC[C@H](O)CC[C@@H]1[C@H]2Cc3cccc(OCC(=O)O)c3C[C@H]2C[C@H]1O
Treprostinil
CCO
ethanol
O
water
OCCNCCO
diethanolamine

Reagenzien

Keine

Lösungsmittel

CC(C)=O
acetone

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    workup.DISSOLUTIONdissolved
  2. 2
    TemperaturThe solution is heated
  3. 3
    Temperaturduring cooling

Vorschrift

Treprostinil acid is dissolved in a 1:1 molar ratio mixture of ethanol:water and diethanolamine is added and dissolved. The solution is heated and acetone is added as an antisolvent during cooling.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09422223B2uspto-grants-2016_08