Reaktion #157131

ord-6afc93268c104228859111cfbfd1091d

Reaktionsgleichung

Nc1cc(Cl)nc(C(F)(F)F)n1
6-chloro-2-(trifluoromethyl)pyrimidin-4-amine
CC(C)(C)OC(=O)OC(=O)OC(C)(C)C
BOC2O
→
CC(C)(C)OC(=O)Nc1cc(Cl)nc(C(F)(F)F)n1
tert-butyl 6-chloro-2-(trifluoromethyl)pyrimidin-4-ylcarbamate

Edukte

Nc1cc(Cl)nc(C(F)(F)F)n1
6-chloro-2-(trifluoromethyl)pyrimidin-4-amine
CC(C)(C)OC(=O)OC(=O)OC(C)(C)C
BOC2O

Reagenzien

CN(C)c1ccncc1
DMAP

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Method 24 was followed using 6-chloro-2-(trifluoromethyl)pyrimidin-4-amine (1.0 equiv.), BOC2O (1.0 equiv.), and DMAP (cat.) to afford tert-butyl 6-chloro-2-(trifluoromethyl)pyrimidin-4-ylcarbamate in 64%. LCMS (m/z): 298.1 (MH+); LC Rt=4.73 min.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08822497B2uspto-grants-2014_09