Reaktion #157095

ord-ea1c55dd6a6140a692a0fa599397662c

Reaktionsgleichung

O=[N+]([O-])c1cnccc1Cl
4-chloro-3-nitropyridine
O[C@H]1CCCNC1
(S)-3-hydroxypiperidine
CCN(CC)CC
triethylamine
→
O=[N+]([O-])c1cnccc1N1CCC[C@H](O)C1
(S)-1-(3-nitropyridin-4-yl)piperidin-3-ol

Edukte

O=[N+]([O-])c1cnccc1Cl
4-chloro-3-nitropyridine
O[C@H]1CCCNC1
(S)-3-hydroxypiperidine
CCN(CC)CC
triethylamine

Reagenzien

Keine

Lösungsmittel

CN(C)C=O
DMF

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Method 1 of Example 1 was followed using 1 equivalent each of 4-chloro-3-nitropyridine, (S)-3-hydroxypiperidine and triethylamine in DMF yielding (S)-1-(3-nitropyridin-4-yl)piperidin-3-ol, LCMS (m/z): 224.1 (MH+); LC Rt=1.06 min.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08822497B2uspto-grants-2014_09