Reaktion #157088

ord-952089f710114625848889319359b2da

Reaktionsgleichung

O=C(O)C(F)(F)F
TFA
CC(C)(C)OC(=O)N1CCCC(C)(C(=O)O)C1
1-(tert-butoxycarbonyl)-3-methylpiperidine-3-carboxylic acid
→
CC1(C(=O)O)CCCNC1
3-methylpiperidine-3-carboxylic acid

Edukte

O=C(O)C(F)(F)F
TFA
CC(C)(C)OC(=O)N1CCCC(C)(C(=O)O)C1
1-(tert-butoxycarbonyl)-3-methylpiperidine-3-carboxylic acid

Reagenzien

Keine

Lösungsmittel

ClCCl
CH2Cl2

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Einengenwas concentrated in vacuo
  2. 2
    Sonstigeazeotroped once with toluene

Vorschrift

TFA was added to a solution of 1-(tert-butoxycarbonyl)-3-methylpiperidine-3-carboxylic acid (1 eq) in CH2Cl2 (0.5 M). After stirring for 3 h at it the reaction mixture was concentrated in vacuo and azeotroped once with toluene to give 3-methylpiperidine-3-carboxylic acid (TFA salt). The crude product was used for the next step without further purification.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08822497B2uspto-grants-2014_09