Reaktion #157051

ord-ff1353cb7abf4fd9b1a4615066989560

Reaktionsgleichung

O=[N+]([O-])c1cnccc1N1CCNCC1
1-(3-nitropyridin-4-yl)piperazine
CC(C)(C)OC(=O)NCC(=O)O
N-Boc-glycine
→
CC(C)(C)OC(=O)NCC(=O)N1CCN(c2ccncc2[N+](=O)[O-])CC1
tert-butyl 2-(4-(3-nitropyridin-4-yl)piperazin-1-yl)-2-oxoethylcarbamate
Ausbeute 99.0%

Edukte

O=[N+]([O-])c1cnccc1N1CCNCC1
1-(3-nitropyridin-4-yl)piperazine
CC(C)(C)OC(=O)NCC(=O)O
N-Boc-glycine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following the method of Example 84 (Method 3), 1-(3-nitropyridin-4-yl)piperazine was coupled to N-Boc-glycine yielding tert-butyl 2-(4-(3-nitropyridin-4-yl)piperazin-1-yl)-2-oxoethylcarbamate (99% yield). LCMS (m/z): 365.8 (MH+); LC Rt=1.81 min.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08822497B2uspto-grants-2014_09