Reaktion #157050

Reaktionsgleichung

1-(3-nitropyridin-4-yl)piperazine

N-Boc-beta-alanine

HOAT

EDC

→

tert-butyl 3-(4-(3-nitropyridin-4-yl)piperazin-1-yl)-3-oxopropylcarbamate

Ausbeute 93.0%

Lösungsmittel

EtOAc

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwas washed with H2O, Na2CO3(sat), NaCl(sat.)
2. 2
   Trocknenwas dried over MgSO4
3. 3
   Filtrationwas filtered
4. 4
   Sonstigethe volatiles were removed in vacuo

Vorschrift

A solution containing 1.0 eq each of 1-(3-nitropyridin-4-yl)piperazine, N-Boc-beta-alanine, HOAT and EDC in DCM, at a concentration of 0.1 M, was stirred for 16 hours. The solution was diluted with EtOAc and was washed with H2O, Na2CO3(sat), NaCl(sat.), was dried over MgSO4, was filtered and the volatiles were removed in vacuo yielding tert-butyl 3-(4-(3-nitropyridin-4-yl)piperazin-1-yl)-3-oxopropylcarbamate (93%). LCMS (m/z): 379.9 (MH+); LC Rt=1.92 min.

Quelle