Reaktion #157026

ord-9badc0c721d24566a7bce657b4531b3d

Reaktionsgleichung

CC(=O)c1ccc(Cl)c([N+](=O)[O-])c1
4-chloro-3-nitroacetophenone
CC(C)(C)OC(=O)NC1CCNCC1
4-(N-Boc-amino) piperidine
→
CC(=O)c1ccc(N2CCC(NC(=O)OC(C)(C)C)CC2)c([N+](=O)[O-])c1
tert-butyl 1-(4-acetyl-2-nitrophenyl)piperidin-4-ylcarbamate
Ausbeute 95.0%

Edukte

CC(=O)c1ccc(Cl)c([N+](=O)[O-])c1
4-chloro-3-nitroacetophenone
CC(C)(C)OC(=O)NC1CCNCC1
4-(N-Boc-amino) piperidine
—
TEA

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigeat 55° C.
  2. 2
    Sonstigeovernight

Vorschrift

Method 1 was followed using 4-chloro-3-nitroacetophenone (1.0 eq), 4-(N-Boc-amino) piperidine (1.2 eq), and TEA (2.0 eq) at 55° C. overnight yielding tert-butyl 1-(4-acetyl-2-nitrophenyl)piperidin-4-ylcarbamate (95%). LCMS (m/z): 364.1 (MH+); LC Rt=2.99 min.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08822497B2uspto-grants-2014_09