Reaktion #157025

ord-6248ee4f40be43a3b83ec9a4dcedc2ad

Reaktionsgleichung

O=C(c1ccccc1)c1ccc(Cl)c([N+](=O)[O-])c1
4-chloro-3-nitrobenzophenone
CC(C)(C)OC(=O)N1CCNCC1
1-Boc-piperazine
→
CC(C)(C)OC(=O)N1CCN(c2ccc(C(=O)c3ccccc3)cc2[N+](=O)[O-])CC1
tert-butyl 4-(4-benzoyl-2-nitrophenyl)piperazine-1-carboxylate
Ausbeute 93.0%

Edukte

O=C(c1ccccc1)c1ccc(Cl)c([N+](=O)[O-])c1
4-chloro-3-nitrobenzophenone
CC(C)(C)OC(=O)N1CCNCC1
1-Boc-piperazine
—
TEA

Reagenzien

Keine

Lösungsmittel

CN1CCCC1=O
NMP

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Method 1 was followed using 4-chloro-3-nitrobenzophenone (1.0 eq), 1-Boc-piperazine (1.1 eq), and TEA (2.0 eq) in NMP yielding tert-butyl 4-(4-benzoyl-2-nitrophenyl)piperazine-1-carboxylate (93%). LCMS (m/z): 412.2 (MH+); LC Rt=3.59 min.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08822497B2uspto-grants-2014_09