Reaktion #157023

ord-773c07133921440b9ace2ed353f1ff30

Reaktionsgleichung

O=C(c1ccccc1)c1ccc(Cl)c([N+](=O)[O-])c1
4-chloro-3-nitrobenzophenone
CC(C)(C)OC(=O)NC1CCCNC1
3-(N-Boc-amino) piperidine
→
CC(C)(C)OC(=O)NC1CCCN(c2ccc(C(=O)c3ccccc3)cc2[N+](=O)[O-])C1
tert-butyl 1-(4-benzoyl-2-nitro phenyl)piperidin-3-ylcarbamate
Ausbeute 90.0%

Edukte

O=C(c1ccccc1)c1ccc(Cl)c([N+](=O)[O-])c1
4-chloro-3-nitrobenzophenone
CC(C)(C)OC(=O)NC1CCCNC1
3-(N-Boc-amino) piperidine
—
TEA

Reagenzien

Keine

Lösungsmittel

CN1CCCC1=O
NMP

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Method 1 was followed using 4-chloro-3-nitrobenzophenone (1.0 eq), 3-(N-Boc-amino) piperidine (1.1 eq), and TEA (2.0 eq) in NMP yielding tert-butyl 1-(4-benzoyl-2-nitro phenyl)piperidin-3-ylcarbamate (90%). LCMS (m/z): 426.2 (MH+); LC Rt=3.49 min.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08822497B2uspto-grants-2014_09