Reaktion #1569784

Reaktionsgleichung

1-(4-chlorobutyl)-1H-benzotriazole

4-(4-pyridyl)piperazine

diisopropylethylamine

potassium iodide

→

compound

Ausbeute 65.4%

1-(4-(4-(4-pyridyl)piperazine-1-yl)butyl)-1H-benzotriazole

Ausbeute 65.4%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwere respectively added
2. 2
   workup.ADDITIONmixed
3. 3
   Temperaturheated
4. 4
   Temperaturrefluxed
5. 5
   Sonstigeto react for 20 hours
6. 6
   Filtrationfiltered
7. 7
   EinengenThe filtrate was concentrated
8. 8
   Sonstigeto produce oily products
9. 9
   workup.ADDITIONtreated by chromatography with neutral Al2O3
10. 10
    Sonstigepurified
11. 11
    Wascheneluted with dichloromethane

Vorschrift

1-(4-chlorobutyl)-1H-benzotriazole (7.55 g, 0.036 mol) was dissolved into 100 ml of acetonitrile, 4-(4-pyridyl)piperazine (4.9 g, 0.03 mol), diisopropylethylamine (15.5 g, 0.12 mol) and potassium iodide (5.0 g, 0.03 mol) were respectively added. The mixture was stirred and mixed, then heated and refluxed to react for 20 hours. The mixture was cooled down to ambient temperature and filtered. The filtrate was concentrated to produce oily products, and treated by chromatography with neutral Al2O3 and purified, eluted with dichloromethane to produce 6.6 g compound (I-44) with a yield of 65.3%. ESI-MS [M+H]+: m/z 336.2.

Quelle