Reaktion #1569780

Reaktionsgleichung

1-(4-chlorobutyl)-1H-benzotriazole

3-cyano phenylpiperazine

diisopropylethylamine

potassium iodide

→

compound

Ausbeute 70.5%

1-(4-(4-(3-cyanophenyl)piperazine-1-yl)butyl)-1H-benzotriazole

Ausbeute 70.5%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwere respectively added
2. 2
   workup.ADDITIONmixed
3. 3
   Temperaturheated
4. 4
   Temperaturrefluxed
5. 5
   Sonstigeto react for 15 hours
6. 6
   Filtrationfiltered
7. 7
   EinengenThe filtrate was concentrated
8. 8
   Sonstigeto produce oily products
9. 9
   workup.ADDITIONtreated by chromatography with neutral Al2O3
10. 10
    Sonstigepurified
11. 11
    Wascheneluted with dichloromethane

Vorschrift

1-(4-chlorobutyl)-1H-benzotriazole (7.55 g, 0.036 mol) was dissolved into 100 ml of acetonitrile, 3-cyano phenylpiperazine (5.6 g, 0.03 mol), diisopropylethylamine (15.5 g, 0.12 mol) and potassium iodide (5.0 g, 0.03 mol) were respectively added. The mixture was stirred and mixed, then heated and refluxed to react for 15 hours. The mixture was cooled down to ambient temperature and filtered. The filtrate was concentrated to produce oily products, and treated by chromatography with neutral Al2O3 and purified, eluted with dichloromethane to produce 7.6 g compound (I-41) with a yield of 70.5%. ESI-MS [M+H]+: m/z 360.2.

Quelle