Reaktion #1568136

Reaktionsgleichung

1-cyano-4-hydroxy-7-phenoxy-isoquinoline-3-carboxylic acid methyl ester

2-aminomethyl-2-propyl-pentanoic acid tert-butyl ester

→

desired product

Ausbeute 82.5%

2-{[(1-Cyano-4-hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]-methyl}-2-propyl-pentanoic acid tert-butyl ester

Ausbeute 82.5%

Lösungsmittel

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas microwaved at 120° C. for 2 h
2. 2
   TemperaturThe mixture was cooled
3. 3
   Einengenconcentrated with HOAc (0.02 mL)
4. 4
   Sonstigepurified

Vorschrift

A mixture of 1-cyano-4-hydroxy-7-phenoxy-isoquinoline-3-carboxylic acid methyl ester (135 mg) and 2-aminomethyl-2-propyl-pentanoic acid tert-butyl ester (193 mg) in MeOH (2 mL) was microwaved at 120° C. for 2 h. The mixture was cooled, concentrated with HOAc (0.02 mL), the residue was directly column purified to give the desired product (180 mg). LC MS ESI+: 518 (M+1)+.

Quelle