Reaktion #156753

ord-080e814c18744428b9a1b08ec9d8356c

Reaktionsgleichung

COC(=O)[C@@H]1CC[C@H](N)C1
(1R,3S)-methyl 3-aminocyclopentanecarboxylate
O=S(=O)(Cl)c1ccc(-c2ccc(F)cc2F)cc1
2′,4′-difluorobiphenyl-4-sulphonyl chloride
→
COC(=O)[C@@H]1CC[C@H](NS(=O)(=O)c2ccc(-c3ccc(F)cc3F)cc2)C1
title compound
COC(=O)[C@@H]1CC[C@H](NS(=O)(=O)c2ccc(-c3ccc(F)cc3F)cc2)C1
(1R,3S)-Methyl 3-(2′,4′-difluorobiphenyl-4-ylsulfonamido)cyclopentanecarboxylate

Edukte

COC(=O)[C@@H]1CC[C@H](N)C1
(1R,3S)-methyl 3-aminocyclopentanecarboxylate
O=S(=O)(Cl)c1ccc(-c2ccc(F)cc2F)cc1
2′,4′-difluorobiphenyl-4-sulphonyl chloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Using a method analogous to Method A, using (1R,3S)-methyl 3-aminocyclopentanecarboxylate and 2′,4′-difluorobiphenyl-4-sulphonyl chloride, the title compound was obtained as a pale yellow gum.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08822507B2uspto-grants-2014_09