Reaktion #156752

Reaktionsgleichung

(1R,3S)-3-aminocyclopentanecarboxylic acid

methanol

thionyl chloride

→

title compound

(1R,3S)-Methyl 3-aminocyclopentanecarboxylate hydrochloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto warm to room temperature
2. 2
   workup.STIRRINGstirred overnight
3. 3
   SonstigeThe resulting clear solution was evaporated
4. 4
   Sonstigeazeotroped with methanol (2×5 mL)
5. 5
   Sonstigeair-dried

Vorschrift

A suspension of (1R,3S)-3-aminocyclopentanecarboxylic acid (500 mg, 3.8 mmol) in methanol (10 mL) was stirred at 0° C. and thionyl chloride (1.40 mL, 19.3 mmol) was added dropwise. The mixture was allowed to warm to room temperature and stirred overnight. The resulting clear solution was evaporated, azeotroped with methanol (2×5 mL), air-dried and the title compound obtained as a white powder (680 mg).

Quelle