Reaktion #156677

ord-32315e8970054af489e0dc5e5eff74f6

Reaktionsgleichung

O=c1c2ccc(OC[C@H]3CCCO3)cc2ccn1-c1ccc(Br)c(F)c1
2-(4-Bromo-3-fluorophenyl)-6-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-2H-isoquinolin-1-one
CO[C@@H]1CNC[C@H]1N(C)C
((3R*,4R*)-4-methoxy-pyrrolidin-3yl)-dimethylamine
→
CO[C@@H]1CN(c2ccc(-n3ccc4cc(OC[C@H]5CCCO5)ccc4c3=O)cc2F)C[C@H]1N(C)C
2-[4-((3R*,4R*)-3-Dimethylamino-4-methoxy-pyrrolidin-1-yl)-3-fluorophenyl]-6-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-2H-isoquinolin-1-one

Edukte

O=c1c2ccc(OC[C@H]3CCCO3)cc2ccn1-c1ccc(Br)c(F)c1
2-(4-Bromo-3-fluorophenyl)-6-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-2H-isoquinolin-1-one
CO[C@@H]1CNC[C@H]1N(C)C
((3R*,4R*)-4-methoxy-pyrrolidin-3yl)-dimethylamine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeIn this way the product was obtained with molecular weight 481.57 (C27H32FN3O4)

Vorschrift

2-(4-Bromo-3-fluorophenyl)-6-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-2H-isoquinolin-1-one and ((3R*,4R*)-4-methoxy-pyrrolidin-3yl)-dimethylamine were reacted according to Method R1. In this way the product was obtained with molecular weight 481.57 (C27H32FN3O4); MS (ESI): 482 (M+H+).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08822495B2uspto-grants-2014_09