Reaktion #156651

ord-0459cafa960f46af85b0553019880312

Reaktionsgleichung

COc1cc(N2CCc3cc(O)ccc3C2=O)ccc1N1CCCNCC1
2-(4-[1,4]Diazepan-1-yl-3-methoxy-phenyl)-6-hydroxy-3,4-dihydro-2H-isoquinolin-1-one
COCC(C)=O
1-methoxy-propan-2-one
→
COCC(C)N1CCCN(c2ccc(N3CCc4cc(O)ccc4C3=O)cc2OC)CC1
6-Hydroxy-2-{3-methoxy-4-[4-(2-methoxy-1-methyl-ethyl)-[1,4]diazepan-1-yl]-phenyl}-3,4-dihydro-2H-isoquinolin-1-one

Edukte

COc1cc(N2CCc3cc(O)ccc3C2=O)ccc1N1CCCNCC1
2-(4-[1,4]Diazepan-1-yl-3-methoxy-phenyl)-6-hydroxy-3,4-dihydro-2H-isoquinolin-1-one
COCC(C)=O
1-methoxy-propan-2-one

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeIn this way the product was obtained with molecular weight 439.56 (C25H33N3O4)

Vorschrift

2-(4-[1,4]Diazepan-1-yl-3-methoxy-phenyl)-6-hydroxy-3,4-dihydro-2H-isoquinolin-1-one and 1-methoxy-propan-2-one were reacted according to Method J1. In this way the product was obtained with molecular weight 439.56 (C25H33N3O4); MS (ESI): 440 (M+H+).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08822495B2uspto-grants-2014_09