Reaktion #156642

Reaktionsgleichung

2-((R)-4-[1,3′]bipyrrolidinyl-1′-yl-3-fluorophenyl)-6-((Z)-pent-1-enyl)-2H-isoquinolin-1-one

THF

N-methyl-morpholine-N-oxide

water

→

2-((R)-4-[1,3′]Bipyrrolidinyl-1′-yl-3-fluorophenyl)-6-((1R*,2S*)-1,2-dihydroxy-pentyl)-2H-isoquinolin-1-one

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenAfter 48 hours the reaction mixture was concentrated
2. 2
   Sonstigethe residue was purified by preparative HPLC
3. 3
   SonstigeIn this way the product was obtained with molecular weight 479.60 (C28H34FN3O3)

Vorschrift

Firstly, osmium tetroxide (solution in tert.-butanol, 0.1 equiv.) was added to a mixture of 2-((R)-4-[1,3′]bipyrrolidinyl-1′-yl-3-fluorophenyl)-6-((Z)-pent-1-enyl)-2H-isoquinolin-1-one (0.10 g) and THF (10 mL), and then a solution of N-methyl-morpholine-N-oxide (89 mg) in water (1 mL) was added. After 48 hours the reaction mixture was concentrated and the residue was purified by preparative HPLC. In this way the product was obtained with molecular weight 479.60 (C28H34FN3O3); MS (ESI): 480 (M+H+).

Quelle