Reaktion #156640

Reaktionsgleichung

2-((R)-4-[1,3′]bipyrrolidinyl-1′-yl-3-fluorophenyl)-6-hydroxy-2H-isoquinolin-1-one

cesium fluoride

3,7-dioxa-bicyclo[4.1.0]heptane

→

2-((R)-4-[1,3′]Bipyrrolidinyl-1′-yl-3-fluorophenyl)-6-((3R*,4R*)-4-hydroxy-tetrahydro-pyran-3-yloxy)-2H-isoquinolin-1-one

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeIn this way the product was obtained with molecular weight 493.58 (C28H32FN3O4)

Vorschrift

According to Method T, 2-((R)-4-[1,3′]bipyrrolidinyl-1′-yl-3-fluorophenyl)-6-hydroxy-2H-isoquinolin-1-one, with cesium fluoride as auxiliary base, was reacted with 3,7-dioxa-bicyclo[4.1.0]heptane. In this way the product was obtained with molecular weight 493.58 (C28H32FN3O4); MS (ESI): 494 (M+H+).

Quelle