Reaktion #156635

ord-94993ac301d345c49a07f4fd364327eb

Reaktionsgleichung

CCC(O)COc1ccc2c(=O)n(-c3ccc(N4CC[C@@H](N5CCCC5)C4)c(F)c3)ccc2c1
2-((R)-4-[1,3′]bipyrrolidinyl-1′-yl-3-fluorophenyl)-6-(2-hydroxy-butoxy)-2H-isoquinolin-1-one
CI
methyl iodide
→
CCC(COc1ccc2c(=O)n(-c3ccc(N4CC[C@@H](N5CCCC5)C4)c(F)c3)ccc2c1)OC
2-((R)-4-[1,3′]Bipyrrolidinyl-1′-yl-3-fluorophenyl)-6-(2-methoxy-butoxy)-2H-isoquinolin-1-one

Edukte

CCC(O)COc1ccc2c(=O)n(-c3ccc(N4CC[C@@H](N5CCCC5)C4)c(F)c3)ccc2c1
2-((R)-4-[1,3′]bipyrrolidinyl-1′-yl-3-fluorophenyl)-6-(2-hydroxy-butoxy)-2H-isoquinolin-1-one
CI
methyl iodide

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeIn this way the product was obtained with molecular weight 479.60 (C28H34FN3O3)

Vorschrift

According to Method AA, 2-((R)-4-[1,3′]bipyrrolidinyl-1′-yl-3-fluorophenyl)-6-(2-hydroxy-butoxy)-2H-isoquinolin-1-one was reacted with methyl iodide. In this way the product was obtained with molecular weight 479.60 (C28H34FN3O3); MS (ESI): 480 (M+H+).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08822495B2uspto-grants-2014_09