Reaktion #156626

ord-61a0835272c649159c66414f3b067567

Reaktionsgleichung

O=c1c2ccc(OCC3CC3)cc2ccn1-c1ccc(N2CCC3(CCNC3)C2)c(F)c1
6-cyclopropylmethoxy-2-[4-(2,7-diaza-spiro[4.4]non-2-yl)-3-fluorophenyl]-2H-isoquinolin-1-one
FCCBr
1-bromo-2-fluoro-ethane
→
O=c1c2ccc(OCC3CC3)cc2ccn1-c1ccc(N2CCC3(CCN(CCF)C3)C2)c(F)c1
6-Cyclopropylmethoxy-2-{3-fluoro-4-[7-(2-fluoroethyl)-2,7-diaza-spiro[4.4]non-2-yl]-phenyl}-2H-isoquinolin-1-one

Edukte

O=c1c2ccc(OCC3CC3)cc2ccn1-c1ccc(N2CCC3(CCNC3)C2)c(F)c1
6-cyclopropylmethoxy-2-[4-(2,7-diaza-spiro[4.4]non-2-yl)-3-fluorophenyl]-2H-isoquinolin-1-one
FCCBr
1-bromo-2-fluoro-ethane

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeIn this way the product was obtained with molecular weight 479.57 (C28H31F2N3O2)

Vorschrift

According to Method X, 6-cyclopropylmethoxy-2-[4-(2,7-diaza-spiro[4.4]non-2-yl)-3-fluorophenyl]-2H-isoquinolin-1-one was reacted with 1-bromo-2-fluoro-ethane. In this way the product was obtained with molecular weight 479.57 (C28H31F2N3O2); MS (ESI): 480 (M+H+).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08822495B2uspto-grants-2014_09