Reaktion #156608

Reaktionsgleichung

3-methyl-5-p-tolylthiophene-2-carbaldehyde

sodium dihydrogenphosphate

sulfamic acid

hydrochloric acid

sodium chlorite

sodium sulfite

→

3-Methyl-5-p-tolylthiophene-2-carboxylic acid

Lösungsmittel

1,4-dioxane

water

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added
2. 2
   Sonstigedid not rise above 10° C
3. 3
   workup.ADDITIONTwenty minutes after the addition
4. 4
   Extraktionextracted with ethyl acetate
5. 5
   SonstigeThe organic phase was dried
6. 6
   Einengenconcentrated
7. 7
   SonstigeThe product with the molecular weight of 232.30 (C13H12O2S) was obtained in this way

Vorschrift

A solution of 3-methyl-5-p-tolylthiophene-2-carbaldehyde (2.6 g) in 1,4-dioxane (30 mL) was mixed with a solution of sodium dihydrogenphosphate (5.77 g) in water, and sulfamic acid (1.87 g) was added. At 10° C., a solution of sodium chlorite (1.52 g) in water (20 mL) was added dropwise in such a way that the temperature did not rise above 10° C. Twenty minutes after the addition was complete, sodium sulfite (1.98 g) was added and the mixture was stirred for 15 minutes. The reaction mixture was acidified with hydrochloric acid and extracted with ethyl acetate. The organic phase was dried and concentrated. The product with the molecular weight of 232.30 (C13H12O2S) was obtained in this way; MS (ESI): 233 (M+H+).

Quelle