Reaktion #1565873

Reaktionsgleichung

sulfuric acid

2-Ethylpyrazolo[1,5-a]pyridine-3-carboxylic acid

ethyl acetate

sodium bicarbonate

→

desired compound

Ausbeute 82.0%

2-Ethylpyrazolo[1,5-a]pyridine

Ausbeute 82.0%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled to 20° C
2. 2
   SonstigeThe extracts were separated
3. 3
   Extraktionthe aqueous layer was extracted with ethyl acetate
4. 4
   TrocknenThe combined extracts were dried (sodium sulfate)
5. 5
   Sonstigeevaporated

Vorschrift

2-Ethylpyrazolo[1,5-a]pyridine-3-carboxylic acid (4.1 g, 22 mmol) was stirred in water (100 mL) and sulfuric acid (2.5 mL) was added. The mixture was heated at 70° C. for 2 h and cooled to 20° C. The mixture was poured into ethyl acetate and neutralized with saturated sodium bicarbonate. The extracts were separated and the aqueous layer was extracted with ethyl acetate. The combined extracts were dried (sodium sulfate) and evaporated to give the desired compound (2.6 g, 82%). LCMS for C9H11N2 (M+H)+: m/z=147.1. 1H NMR (300 MHz, DMSO-d6): δ 8.52 (m, 1 H), 7.57 (m, 1 H), 7.11 (m, 1 H), 6.75 (m, 1 H), 6.38 (s, 1 H), 2.73 (m, 2 H), 1.22 (m, 3 H).

Quelle