Reaktion #1564

Reaktionsgleichung

N-[(4-fluoro-3-nitrophenyl)carbamoyl]glycine, ethyl ester

hydrogen

→

title product

Ausbeute 60.8%

N-[(3-Amino-4-fluorophenyl)-carbamoyl]glycine, ethyl ester

Ausbeute 60.8%

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction mixture is then filtered
2. 2
   Temperaturcooled in an ice-bath until a solid forms
3. 3
   FiltrationThe solid is collected by filtration
4. 4
   Sonstigeair-dried

Vorschrift

A mixture of N-[(4-fluoro-3-nitrophenyl)carbamoyl]glycine, ethyl ester (8 g, 0.029 mol) and 5% platinum on activated carbon (0.5 g) in ethyl acetate is hydrogenated at 50 psi until hydrogen uptake is complete. The reaction mixture is then filtered and cooled in an ice-bath until a solid forms. The solid is collected by filtration and air-dried to give the title product as a white solid (4.5 g, mp 152°-153° C.).

Quelle