Reaktion #1563934

Reaktionsgleichung

NaBH4

5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole

→

title compound

Ausbeute 79.8%

2-(2,5-difluorophenyl)pyrrolidine

Ausbeute 79.8%

Lösungsmittel

MeOH H2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction mixture was quenched with 1N aqueous HCl solution
2. 2
   Extraktionextracted with DCM
3. 3
   Trocknendried over anhydrous sodium sulphate
4. 4
   Einengenconcentrated under reduced pressure

Vorschrift

NaBH4 (12 g, 314.9 mmol) was added to a solution of 5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole (28.5 g, 157.4 mmol) in a mixture of MeOH:H2O (4:1, 250 mL) and stirring was continued at 25-35° C. for 2 h. The reaction mixture was quenched with 1N aqueous HCl solution and basified with 2N aqueous NaOH solution, extracted with DCM, dried over anhydrous sodium sulphate and concentrated under reduced pressure to afford 23 g of the title compound.

Quelle