Reaktion #156308

Reaktionsgleichung

4-{[(2S)-2-fluoropropyl]oxy}pyridine

acetic acid

→

4-{[(2S)-2-fluoropropyl]oxy}piperidine

Ausbeute 43.2%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added
2. 2
   FiltrationThe reaction mixture was filtered through celite
3. 3
   Einengenthe filtrate was concentrated under reduced pressure
4. 4
   SonstigeThe residue was purified by basic silica gel column chromatography (chloroform/methanol)

Vorschrift

2.2 g of 4-{[(2S)-2-fluoropropyl]oxy}pyridine was added to a solution of 22 mL of acetic acid in 22 mL of methanol, and 500 mg of 10% palladium on carbon (wet type) was added thereto under an argon atmosphere. The mixture was stirred at room temperature overnight under a hydrogen atmosphere of 3 atm. The reaction mixture was filtered through celite and the filtrate was concentrated under reduced pressure. The residue was purified by basic silica gel column chromatography (chloroform/methanol) to obtain 988 mg of 4-{[(2S)-2-fluoropropyl]oxy}piperidine.

Quelle