Reaktion #1561572

ord-3a256193d52d4df298e1db2247c67291

Reaktionsgleichung

CC(C)(C)C1CN(CC2OCCc3c(Br)cccc32)CCN1C(=O)[O-]
1,1-dimethylethyl-4-[(5-bromo-3,4-dihydro-1H-isochromen-1-yl)methyl]piperazine-1-carboxylate
C1COCCO1.Cl
HCl dioxane
→
Brc1cccc2c1CCOC2CN1CCNCC1
1-[(5-bromo-3,4-dihydro-1H-isochromen-1-yl)methyl]piperazine

Edukte

CC(C)(C)C1CN(CC2OCCc3c(Br)cccc32)CCN1C(=O)[O-]
1,1-dimethylethyl-4-[(5-bromo-3,4-dihydro-1H-isochromen-1-yl)methyl]piperazine-1-carboxylate
C1COCCO1.Cl
HCl dioxane

Reagenzien

Keine

Lösungsmittel

ClCCl
DCM

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe solvents was removed under vacuum

Vorschrift

A solution of 1,1-dimethylethyl-4-[(5-bromo-3,4-dihydro-1H-isochromen-1-yl)methyl]piperazine-1-carboxylate (480 mg, 1.2 mmol) in 10 mL of DCM was added 10 mL of 4N HCl/dioxane, and then stirred at room temperature for 2 hours. The solvents was removed under vacuum to afford 1-[(5-bromo-3,4-dihydro-1H-isochromen-1-yl)methyl]piperazine.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09018211B2uspto-grants-2015_04