Reaktion #1561478

Reaktionsgleichung

1,1-dimethylethyl-4-[(4-cyano-5-fluoro-2,3-dihydro-1H-inden-1-yl)methyl]piperazine-1-carboxylate

HCl

→

5-fluoro-1-(piperazin-1-ylmethyl)-2,3-dihydro-1H-indene-4-carbonitrile

Lösungsmittel

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvents were removed on a rotary evaporator
2. 2
   workup.DISSOLUTIONthe residue was redissolved in aq NaHCO3 solution
3. 3
   ExtraktionThe solution was extracted with IPA-CHCl3 (3:1) twice (50 mL each)
4. 4
   ExtraktionThe extractions
5. 5
   Trocknendried over sodium sulfate
6. 6
   Einengenconcentrated

Vorschrift

To a solution 1,1-dimethylethyl-4-[(4-cyano-5-fluoro-2,3-dihydro-1H-inden-1-yl)methyl]piperazine-1-carboxylate (0.060 g) in DCM (2 mL) was added 4N HCl (2 mL) at RT. The mixture was allowed to stir at RT for 2 hours. The solvents were removed on a rotary evaporator, and the residue was redissolved in aq NaHCO3 solution. The solution was extracted with IPA-CHCl3 (3:1) twice (50 mL each). The extractions were combined, dried over sodium sulfate, and concentrated to give 5-fluoro-1-(piperazin-1-ylmethyl)-2,3-dihydro-1H-indene-4-carbonitrile. LC-MS (IE, m/z): 260 [M+1]+.

Quelle