Reaktion #156058

ord-117ba5ff125d4e0ab7236052a3370e5f

Reaktionsgleichung

Cl.O=C(c1ccc(-c2cnco2)cc1)N(C1CCNCC1)C1CC1
N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide hydrochloride
COC(=O)c1cnc(Cl)cn1
5-chloro-pyrazine-2-carboxylic acid methyl ester
→
COC(=O)c1cnc(N2CCC(N(C(=O)c3ccc(-c4cnco4)cc3)C3CC3)CC2)cn1
title compound
COC(=O)c1cnc(N2CCC(N(C(=O)c3ccc(-c4cnco4)cc3)C3CC3)CC2)cn1
5-{4-[Cyclopropyl-(4-oxazol-5-yl-benzoyl)-amino]-piperidin-1-yl}-pyrazine-2-carboxylic acid methyl ester

Edukte

Cl.O=C(c1ccc(-c2cnco2)cc1)N(C1CCNCC1)C1CC1
N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide hydrochloride
COC(=O)c1cnc(Cl)cn1
5-chloro-pyrazine-2-carboxylic acid methyl ester

Reagenzien

Keine

Lösungsmittel

CN1CCCC1=O
N-methylpyrrolidinone

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound is prepared from N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide hydrochloride and 5-chloro-pyrazine-2-carboxylic acid methyl ester following a procedure analogous to that described in Example 19 using N-methylpyrrolidinone as solvent. LC (method 16): tR=0.44 min; Mass spectrum (ESI+): m/z=448 [M+H]+.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08822471B2uspto-grants-2014_09