Reaktion #155997

ord-ed2ab07251054b7c87522fd99a9dee05

Reaktionsgleichung

N#CN1CCC(N(C(=O)c2ccc(-c3cnco3)cc2)C2CC2)CC1
N-(1-cyano-piperidin-4-yl)-N-cyclopropyl-4-oxazol-5-yl-benzamide
N=C(NO)c1cccnc1
N-hydroxy-nicotinamidine
→
O=C(c1ccc(-c2cnco2)cc1)N(C1CC1)C1CCN(c2nc(-c3cccnc3)no2)CC1
title compound
O=C(c1ccc(-c2cnco2)cc1)N(C1CC1)C1CCN(c2nc(-c3cccnc3)no2)CC1
N-Cyclopropyl-4-oxazol-5-yl-N-[1-(3-pyridin-3-yl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-benzamide

Edukte

N#CN1CCC(N(C(=O)c2ccc(-c3cnco3)cc2)C2CC2)CC1
N-(1-cyano-piperidin-4-yl)-N-cyclopropyl-4-oxazol-5-yl-benzamide
N=C(NO)c1cccnc1
N-hydroxy-nicotinamidine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound is prepared from N-(1-cyano-piperidin-4-yl)-N-cyclopropyl-4-oxazol-5-yl-benzamide and N-hydroxy-nicotinamidine following a procedure analogous to that described in Example 1. LC (method 6): tR=1.57 min; Mass spectrum (ESI+): m/z=457 [M+H]+.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08822471B2uspto-grants-2014_09