Reaktion #155985

ord-04627bb7080141bb8a5ebba115e5a252

Reaktionsgleichung

N#CN1CCC(N(C(=O)c2ccc(-c3cnco3)cc2)C2CC2)CC1
N-(1-cyano-piperidin-4-yl)-N-cyclopropyl-4-oxazol-5-yl-benzamide
CC(C)(C)C(=N)NO
N-hydroxy-2,2-dimethyl-propionamidine
→
CC(C)(C)c1noc(N2CCC(N(C(=O)c3ccc(-c4cnco4)cc3)C3CC3)CC2)n1
title compound
CC(C)(C)c1noc(N2CCC(N(C(=O)c3ccc(-c4cnco4)cc3)C3CC3)CC2)n1
N-[1-(3-tert-Butyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-N-cyclopropyl-4-oxazol-5-yl-benzamide

Edukte

N#CN1CCC(N(C(=O)c2ccc(-c3cnco3)cc2)C2CC2)CC1
N-(1-cyano-piperidin-4-yl)-N-cyclopropyl-4-oxazol-5-yl-benzamide
CC(C)(C)C(=N)NO
N-hydroxy-2,2-dimethyl-propionamidine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound is prepared from N-(1-cyano-piperidin-4-yl)-N-cyclopropyl-4-oxazol-5-yl-benzamide and N-hydroxy-2,2-dimethyl-propionamidine following a procedure analogous to that described in Example 1. LC (method 6): tR=1.68 min; Mass spectrum (ESI+): m/z=436 [M+H]+.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08822471B2uspto-grants-2014_09