Reaktion #155962

ord-60bf5a2ea0b34182be7b171335a2a86c

Reaktionsgleichung

Fc1cc(Br)cc(F)c1I
5-bromo-1,3-difluoro-2-iodo-benzene
CC(C)[Si](c1ncc(B2OC(C)(C)C(C)(C)O2)o1)(C(C)C)C(C)C
5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-2-triisopropylsilanyl-oxazole
→
Fc1cc(Br)cc(F)c1-c1cnco1
title compound
Fc1cc(Br)cc(F)c1-c1cnco1
5-(4-Bromo-2,6-difluoro-phenyl)-oxazole

Edukte

Fc1cc(Br)cc(F)c1I
5-bromo-1,3-difluoro-2-iodo-benzene
CC(C)[Si](c1ncc(B2OC(C)(C)C(C)(C)O2)o1)(C(C)C)C(C)C
5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-2-triisopropylsilanyl-oxazole
—
Intermediate 27

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound is prepared from 5-bromo-1,3-difluoro-2-iodo-benzene and 5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-2-triisopropylsilanyl-oxazole following a procedure analogous to that described in Intermediate 27. LC (method 1): tR=1.18 min; Mass spectrum (ESI+): m/z=260 [M+H]+.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08822471B2uspto-grants-2014_09