Reaktion #1558862

Reaktionsgleichung

6-methoxypyridin-3-ol

K2CO3

bromomethyl methyl ether

→

2-methoxy-5-(methoxymethoxy)pyridine

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction mixture was filtered
2. 2
   Einengenthe filtrate was concentrated
3. 3
   SonstigeThe residue was purified on silica gel with 25% EtOAc/hexanes as eluent

Vorschrift

To a mixture of 6-methoxypyridin-3-ol (25 g, 0.2 mol) and K2CO3 (82.8 g, 0.6 mol) in DMF (250 mL) was added bromomethyl methyl ether (30 g, 0.24 mmol) slowly at rt for a period of 1 h. The reaction mixture was filtered and the filtrate was concentrated. The residue was purified on silica gel with 25% EtOAc/hexanes as eluent to give 2-methoxy-5-(methoxymethoxy)pyridine (20 g, 59%) as a colorless oil. LRMS (M+H+) m/z 170.1

Quelle