Reaktion #155675

Reaktionsgleichung

2-amino-9,10-dihydrophenanthrene

HCl

potassium iodide

sodium nitrite

→

pale yellow solid

Ausbeute 62.0%

2-iodo-9,10-dihydrophenanthrene

Ausbeute 62.0%

Lösungsmittel

dichloromethane

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder heat
2. 2
   Temperaturthe mixture was cooled with ice
3. 3
   workup.STIRRINGthe whole was stirred at room temperature for 3 hours
4. 4
   ExtraktionAfter that, the mixture was extracted with dichloromethane
5. 5
   WaschenThe organic layer was repeatedly washed with an aqueous solution of potassium carbonate
6. 6
   Trocknenwas then dried with magnesium sulfate
7. 7
   SonstigeAfter that, the solvent was removed by distillation under reduced pressure
8. 8
   SonstigeThe residue was purified by silica gel column chromatography

Vorschrift

Under an argon atmosphere, 220 g of 2-amino-9,10-dihydrophenanthrene, 3 L of 3N HCl, and 2 L of acetic acid were added, and then the mixture was stirred for 3 hours under heat. After having been cooled to room temperature, the mixture was cooled with ice, and then an aqueous solution of 91 g of sodium nitrite was dropped to the mixture. After the resultant mixture had been stirred for 1 hour under ice cooling, an aqueous solution of 660 g of potassium iodide was added to the mixture. Subsequently, 2 L of dichloromethane were added to the mixture, and then the whole was stirred at room temperature for 3 hours. After that, the mixture was extracted with dichloromethane. The organic layer was repeatedly washed with an aqueous solution of potassium carbonate, and was then dried with magnesium sulfate. After that, the solvent was removed by distillation under reduced pressure. The residue was purified by silica gel column chromatography. Thus, 210 g of a pale yellow solid were obtained (in 62% yield).

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