Reaktion #155642

Reaktionsgleichung

2-amino-2-methyl-1-propanol

4-tert-butylbenzoyl chloride

→

title compound

Ausbeute 105.5%

4-tert-Butyl-N-(2-hydroxy-1,1-dimethyl-ethyl)-benzamide

Ausbeute 105.5%

Lösungsmittel

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigefitted with a stir bar
2. 2
   TemperaturEstablished and maintained nitrogen atmosphere
3. 3
   SonstigeA white precipitate formed
4. 4
   workup.STIRRINGStirred at room temperature overnight
5. 5
   SonstigeRemoved the solids
6. 6
   Filtrationby filtration
7. 7
   Waschenwashed with CH2Cl2
8. 8
   SonstigeRemoved the solvent from the filtrate on rotavap
9. 9
   Sonstigedried at 60°/4 torr

Vorschrift

30.95 g (347 mmol) of 2-amino-2-methyl-1-propanol was weighed into a 500 mL Erlenmeyer flask fitted with a stir bar and septum. Added 200 mL CH2Cl2. Established and maintained nitrogen atmosphere. Stirred the solution in an ice/water bath. Added 34 mL (174 mmol) of 4-tert-butylbenzoyl chloride dropwise over 30 min. A white precipitate formed. Stirred at room temperature overnight. Removed the solids by filtration and washed with CH2Cl2. Removed the solvent from the filtrate on rotavap and dried at 60°/4 torr to obtain 45.79 g of the title compound as a light yellow resin. MS (EST) 248 (M−H)−.

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