Reaktion #1555365

ord-4080ff59bbcb4f06982bc90b47d82717

Reaktionsgleichung

N#Cc1ccc(-c2cn(Cc3cccc(C(=O)O)c3)nn2)cc1
3-[4-(4-cyano-phenyl)-[1,2,3]triazol-1-ylmethyl]-benzoic acid
CC(C)(C)OC(=O)N[C@@H]1CCc2nc(N)sc2C1
((R)-2-amino-4,5,6,7-tetrahydro-benzothiazol-6-yl)-carbamic acid tert-butyl ester
→
CC(C)(C)OC(=O)N[C@@H]1CCc2nc(NC(=O)c3cccc(Cn4cc(-c5ccc(C#N)cc5)nn4)c3)sc2C1
((R)-2-{3-[4-(4-cyano-phenyl)-1,2,3-triazol-1-ylmethyl]-benzoylamino}-4,5,6,7-tetrahydro-benzothiazol-6-yl)-carbamic acid tert-butyl ester

Edukte

N#Cc1ccc(-c2cn(Cc3cccc(C(=O)O)c3)nn2)cc1
3-[4-(4-cyano-phenyl)-[1,2,3]triazol-1-ylmethyl]-benzoic acid
CC(C)(C)OC(=O)N[C@@H]1CCc2nc(N)sc2C1
((R)-2-amino-4,5,6,7-tetrahydro-benzothiazol-6-yl)-carbamic acid tert-butyl ester

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

React 3-[4-(4-cyano-phenyl)-[1,2,3]triazol-1-ylmethyl]-benzoic acid and ((R)-2-amino-4,5,6,7-tetrahydro-benzothiazol-6-yl)-carbamic acid tert-butyl ester under TBTU coupling conditions as described in Example 1 to give ((R)-2-{3-[4-(4-cyano-phenyl)-1,2,3-triazol-1-ylmethyl]-benzoylamino}-4,5,6,7-tetrahydro-benzothiazol-6-yl)-carbamic acid tert-butyl ester

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09000154B2uspto-grants-2015_04