Reaktion #155376

ord-4dd9c14257d746a4973130c2e6fabeb5

Reaktionsgleichung

CCCCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCCC(=O)[O-].[Mg+2]

magnesium stearate

CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1.O=C(O)CC(O)(CC(=O)O)C(=O)O

Fentanyl citrate

→

C=CCN1CC[C@]23c4c5ccc(O)c4O[C@H]2C(=O)CC[C@@]3(O)[C@H]1C5.CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1

Naloxone Fentanyl

Edukte

—

Croscarmellose sodium

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen

See reaction.notes.procedure_details.

Aufarbeitung

1
workup.ADDITIONMixing

Vorschrift

Fentanyl citrate was added to the carrier material in amounts corresponding to a batch size of 300 tablets. Mixing was carried out under the same conditions as those described in Example 1. Croscarmellose sodium and silicified microcrystalline cellulose, and then magnesium stearate, were added and admixed under the same conditions as those described in Example 1.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08821914B2uspto-grants-2014_09