Reaktion #155319

Reaktionsgleichung

5-Methylbenzofuran-7-ylamine

ethanol

→

5-methyl-2,3-dihydrobenzofuran-7-ylamine

Ausbeute 87.6%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigefollowed by conduction of catalytic reduction at room temperature under ordinary pressure
2. 2
   SonstigeThe catalyst was removed by celite filtration
3. 3
   Sonstigecondensed under reduced pressure
4. 4
   Trocknendried over anhydrous magnesium sulfate
5. 5
   Einengenconcentrated to dryness under reduced pressure

Vorschrift

5-Methylbenzofuran-7-ylamine (1.3 g, 8.8 mmol) and 10% palladium carbon (500 mg) were added to ethanol (50 ml), followed by conduction of catalytic reduction at room temperature under ordinary pressure. The catalyst was removed by celite filtration, and the obtained filtrate was condensed under reduced pressure. The residue was dissolved in dichloromethane, dried over anhydrous magnesium sulfate, and then concentrated to dryness under reduced pressure, giving a white powder of 5-methyl-2,3-dihydrobenzofuran-7-ylamine (1.15 g, yield: 87%).

Quelle