Reaktion #1553094

Reaktionsgleichung

5-hydroxy-6-ethyl-2,4-diaminopyrimidine

lithium hydroxide monohydrate

3-Bromo-1-propanol

→

5-(3′-hydroxypropoxy)-6-ethyl-2,4-diaminopyrimidine

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITleft
2. 2
   workup.STIRRINGstirring at room temperature for 10 hours
3. 3
   SonstigeRemoval of DMF
4. 4
   Sonstigegave the crude product
5. 5
   Sonstigefurther purified by crystallization with water

Vorschrift

A mixture of 5-hydroxy-6-ethyl-2,4-diaminopyrimidine (6) (3 mmol) and lithium hydroxide monohydrate (6 mmol) in N,N-dimethylformamide (DMF) (10 ml) was stirred at room temperature for 2 hours under nitrogen. 3-Bromo-1-propanol (3 mmol) was added and left stirring at room temperature for 10 hours. Removal of DMF gave the crude product, further purified by crystallization with water to yield the pure 5-(3′-hydroxypropoxy)-6-ethyl-2,4-diaminopyrimidine (7).

Quelle