Reaktion #1552193

Reaktionsgleichung

t-Butyl 4-(1-methylpiperidine-4-yloxy)-3-(trifluoromethyl)phenylcarbamate

TFA

→

title compound

Ausbeute 77.0%

4-(1-Methylpiperidine-4-yloxy)-3-(trifluoromethyl)benzeneamine

Ausbeute 77.0%

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated
2. 2
   workup.ADDITIONThe reaction mixture was diluted with ethylene chloride
3. 3
   Waschenwashed with sat. NaHCO3 solution
4. 4
   TrocknenThe organic layer was dried with Na2SO4
5. 5
   Filtrationfiltered
6. 6
   Einengenconcentrated

Vorschrift

t-Butyl 4-(1-methylpiperidine-4-yloxy)-3-(trifluoromethyl)phenylcarbamate (82 mg, 0.299 mmol) was dissolved in methylene chloride (1 mL), and TFA (1 mL) was added thereto. The reaction mixture was stirred at room temperature for 2 hours and then concentrated. The reaction mixture was diluted with ethylene chloride and washed with sat. NaHCO3 solution. The organic layer was dried with Na2SO4, filtered and concentrated to obtain the title compound (63 mg, 77%) without further purification.

Quelle