Reaktion #1552191

Reaktionsgleichung

Methyl 4-(1-methylpiperidine-4-yloxy)-3-(trifluoromethyl)benzoate

NaOH

HCl

→

title compound

Ausbeute 80.1%

4-(1-Methylpiperidine-4-yloxy)-3-(trifluoromethyl)benzoic acid

Ausbeute 80.1%

Lösungsmittel

THF

MeOH

H2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled to room temperature
2. 2
   EinengenThe reaction mixture was concentrated
3. 3
   workup.ADDITIONa mixed solvent (DCM/MeOH=5/1) was added
4. 4
   FiltrationThe remaining solid was filtered
5. 5
   Einengenthe filtrate was concentrated

Vorschrift

Methyl 4-(1-methylpiperidine-4-yloxy)-3-(trifluoromethyl)benzoate (512 mg, 1.61 mmol) was dissolved in a mixture of THF (1.5 mL), MeOH (1.5 mL) and H2O (1.5 mL), and then NaOH (193 mg, 4.84 mmol) was added thereto. The reaction mixture was stirred at 90° C. for 22 hours and cooled to room temperature, and 1N HCl was added dropwise thereto to pH 4. The reaction mixture was concentrated, and a mixed solvent (DCM/MeOH=5/1) was added thereto. The remaining solid was filtered, and the filtrate was concentrated to obtain the title compound (391 mg, 80%) without further purification.

Quelle