Reaktion #1551448

Reaktionsgleichung

2-chloro-5-pyridylmethylamine

1-cyano-2-propanone

→

compound

Ausbeute 85.0%

2-(2-chloro-5-pyridylmethylamino)-1-cyano-1-propene

Ausbeute 85.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISTILLATIONThe solvent was then distilled off
2. 2
   Sonstigethe residue was purified by column chromatography on silica gel

Vorschrift

1.4 g of 2-chloro-5-pyridylmethylamine and 0.8 g of 1-cyano-2-propanone were mixed and the mixture was stirred at room temperature over night. The solvent was then distilled off and the residue was purified by column chromatography on silica gel to afford 1.7 g of compound No. 528. m.p. 95°-98° C.

Quelle