Reaktion #1550155

Reaktionsgleichung

(±)-7-Hydroxy-6-methoxy-1-(3,4-dimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

N-acetyl-L-leucine

→

(-)-7-hydroxy-6-methoxy-1-(3,4-dimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

N-acetyl-L-leucinate

Lösungsmittel

methanol

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solution obtained
2. 2
   Einengenis concentrated
3. 3
   Sonstigeby evaporating in a vacuum
4. 4
   workup.ADDITIONAfter the addition of isopropanol/diethyl ether and recrystallisation from the same solvent mixture

Vorschrift

18.9 g. (57.4 mmol) (±)-7-Hydroxy-6-methoxy-1-(3,4-dimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline are dissolved at 60° C. in 70 ml. methanol and mixed with a solution of 9.94 g. (57.4 mmol) N-acetyl-L-leucine in 50 ml. methanol, also heated to 60° C. The solution obtained is concentrated by evaporating in a vacuum. After the addition of isopropanol/diethyl ether and recrystallisation from the same solvent mixture, there is obtained the N-acetyl-L-leucinate of (-)-7-hydroxy-6-methoxy-1-(3,4-dimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline; m.p. 179°-186° C.

Quelle