Reaktion #1549538

Reaktionsgleichung

2,3-dihydro-2,2-dimethyl-6-(2-oxo-propoxy)-4H-1,3-benzoxazin-4-one

4-benzyloxy-α-(aminomethyl)benzyl alcohol

hydrogen

→

N-[2-(3-carbamoyl-4-hydroxy-phenoxy)-1-methyl-ethyl]-aminomethyl-benzyl alcohol

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe catalyst is filtered off
2. 2
   workup.ADDITIONafter adding 40 ml of isopropylamine
3. 3
   Temperaturthe solution is refluxed for 1 hour
4. 4
   SonstigeEvaporation of the reaction mixture

Vorschrift

A solution of 9.6 g of 2,3-dihydro-2,2-dimethyl-6-(2-oxo-propoxy)-4H-1,3-benzoxazin-4-one and 9.37 g of 4-benzyloxy-α-(aminomethyl)benzyl alcohol in 250 ml of methanol is hydrogenated analogously to Example 1 until one equivalent of hydrogen has been taken up. The catalyst is filtered off and, after adding 40 ml of isopropylamine, the solution is refluxed for 1 hour. Evaporation of the reaction mixture yields 4-benzyloxy-α-[N-[2-(3-carbamoyl-4-hydroxy-phenoxy)-1-methyl-ethyl]-aminomethyl-benzyl alcohol in the form of a crystalline mass which can be hydrogenated without further purification.

Quelle