Reaktion #1545010

ord-ba68b961461c45738a58765509742803

Reaktionsgleichung

CC(=O)OC[C@@H](COC(N)=O)c1ccccc1C(F)(F)F
(S)-3-acetoxy-2-(o-trifluoromethylphenyl)propanol carbamate
CC(=O)OC[C@@H](COC(N)=O)c1ccccc1
(S)-3-acetoxy-2-phenylpropanol carbamate
→
NC(=O)OC[C@H](CO)c1ccccc1C(F)(F)F
title compound
Ausbeute 63.5%
NC(=O)OC[C@H](CO)c1ccccc1C(F)(F)F
(S)-2-(o-Trifluoromethylphenyl)-1,3-propanediol Monocarbamate
Ausbeute 63.5%

Edukte

CC(=O)OC[C@@H](COC(N)=O)c1ccccc1C(F)(F)F
(S)-3-acetoxy-2-(o-trifluoromethylphenyl)propanol carbamate
CC(=O)OC[C@@H](COC(N)=O)c1ccccc1
(S)-3-acetoxy-2-phenylpropanol carbamate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was synthesized in a similar manner to that of Example XXII, except that (S)-3-acetoxy-2-(o-trifluoromethylphenyl)propanol carbamate, instead of (S)-3-acetoxy-2-phenylpropanol carbamate, was used as a starting material. Yield 63.5%. Purity 99.4%.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05849772uspto-grants-1998_12