Reaktion #1544683

Reaktionsgleichung

4-(2-benzyloxyethyl) phenyl boronic acid

2-chloro-5-decyloxypyrimidine

sodium carbonate

toluene

→

2-{4-(5-decyloxypyrimidine-2-yl) phenyl}ethylbenzylether

Ausbeute 62.0%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextraction with toluene
2. 2
   TrocknenThen, the extracted solution was dried with anhydrous sodium sulfate
3. 3
   SonstigeThe solvent was removed by filtration
4. 4
   Sonstigerefining was performed by recrystallization (toluene/methanol) so that 9.30 g of 2-{4-(5-decyloxypyrimidine-2-yl) phenyl}ethylbenzylether
5. 5
   Sonstigewas obtained (yield 62%)

Vorschrift

8.62 g (33.7 mmol) of 4-(2-benzyloxyethyl) phenyl boronic acid, 9.13 g (33.7 mmol) of 2-chloro-5-decyloxypyrimidine, 1.29 g of tetrakis (triphenylphosphine) palladium, 54 ml of 2M-sodium carbonate solution, 54 ml of toluene and 27 ml of ethanol were heated at 80° C. for 4 hours under presence of nitrogen. After reactions had been completed, extraction with toluene was performed. Then, the extracted solution was dried with anhydrous sodium sulfate. The solvent was removed by filtration, and then refining was performed by recrystallization (toluene/methanol) so that 9.30 g of 2-{4-(5-decyloxypyrimidine-2-yl) phenyl}ethylbenzylether was obtained (yield 62%).

Quelle