Reaktion #1544681

Reaktionsgleichung

toluene

4-(2-benzyloxyethyl) phenylboronic acid

2-chloro-5-decylpyrimidine

sodium carbonate

→

2-{4-(5-decylpyrimidine-2-yl) phenyl}ethylbenzylether

Ausbeute 77.0%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextraction with toluene
2. 2
   Trocknenthe extracted solution was dried with anhydrous sodium sulfate
3. 3
   SonstigeThe solvent was removed by filtration and refining
4. 4
   Sonstigewas performed by recrystallization (toluene/methanol) so that 1.65 g of 2-{4-(5-decylpyrimidine-2-yl) phenyl}ethylbenzylether
5. 5
   Sonstigewas obtained (yield 77%)

Vorschrift

1.27 g (4.96 mmol) of 4-(2-benzyloxyethyl) phenylboronic acid, 1.26 g (4.96 mmol) of 2-chloro-5-decylpyrimidine, 0.19 g of tetrakis (triphenylphosphine) palladium, 8 ml of 2M sodium carbonate, 8 ml of toluene and 4 ml of ethanol were, under presence of nitrogen, heated at 80° C. for 3 hours. After the reactions had been completed, extraction with toluene was performed and the extracted solution was dried with anhydrous sodium sulfate. The solvent was removed by filtration and refining was performed by recrystallization (toluene/methanol) so that 1.65 g of 2-{4-(5-decylpyrimidine-2-yl) phenyl}ethylbenzylether was obtained (yield 77%).

Quelle