Reaktion #1543772

Reaktionsgleichung

hydrogen chloride

(2R,4R)-2-[2-{4-fluoro-2-[2-(4-fluoro-3-methoxyphenyl)ethyl]phenoxy}ethyl]-4-lauroyloxy-1-methylpyrrolidine

→

title compound

Ausbeute 67.0%

(2R,4R)-2-[2-{4-Fluoro-2-[2-(4-fluoro-3-methoxyphenyl)ethyl]phenoxy}ethyl]-4-lauroyloxy-1-methylpyrrolidine hydrochloride

Ausbeute 67.0%

Lösungsmittel

dioxane

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe solution was then concentrated by evaporation under reduced pressure
2. 2
   workup.ADDITIONHexane was added to the residue
3. 3
   Sonstigethe crystals which precipitated
4. 4
   Filtrationwere collected by filtration
5. 5
   Sonstigedried in vacuo

Vorschrift

684 mg of (2R,4R)-2-[2-{4-fluoro-2-[2-(4-fluoro-3-methoxyphenyl)ethyl]phenoxy}ethyl]-4-lauroyloxy-1-methylpyrrolidine [prepared as described in step (a) above] were dissolved in 10 ml of dioxane, and 0.45 ml of a 4N solution of hydrogen chloride in dioxane was added to the resulting solution. The solution was then concentrated by evaporation under reduced pressure. Hexane was added to the residue, and the crystals which precipitated were collected by filtration, and dried in vacuo, to give 485 mg (yield 67%) of the title compound as colorless crystals, melting at 49°-53° C.

Quelle