Reaktion #1543744

Reaktionsgleichung

hydrogen chloride

(2R,4R)-2-[2-{2-[2-(3,4-difluorophenyl)ethyl]-4-fluorophenoxy}-ethyl]-4-hydroxy-1-methylpyrrolidine

→

title compound

Ausbeute 73.0%

(2R,4R)-2-[2-{2-[2-(3,4-Difluorophenyl)ethyl]-4-fluorophenoxy}ethyl]-4-hydroxy-1-methylpyrrolidine hydrochloride

Ausbeute 73.0%

Lösungsmittel

ethyl acetate

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe crystals which precipitated
2. 2
   Filtrationwere collected by filtration
3. 3
   Sonstigedried in vacuo

Vorschrift

140 mg of (2R,4R)-2-[2-{2-[2-(3,4-difluorophenyl)ethyl]-4-fluorophenoxy}-ethyl]-4-hydroxy-1-methylpyrrolidine [prepared as described in step (c) above] were dissolved in 5 ml of ethyl acetate, and then 0.15 ml of a 4N solution of hydrogen chloride in ethyl acetate were added to the resulting solution. The crystals which precipitated were collected by filtration, and dried in vacuo, to give 113 mg (yield 73%) of the title compound as colorless crystals, melting at 93°-94° C.

Quelle